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Detalhes da Produção
| Tipo | Artigo Publicado |
| Grupo | Produção Bibliográfica |
| Descrição | SIQUEIRA, FRANCIELE MABONI ; THOMPSON, CLAUDIA ELIZABETH ; VIRGINIO, VERIDIANA GOMES ; GONCHOROSKI, TAYLOR ; REOLON, LUCIANO ; ALMEIDA, LUIZ GONZAGA ; DA FONSÊCA, MARBELLA MARIA ; DE SOUZA, RANGEL ; PROSDOCIMI, FRANCISCO ; SCHRANK, IRENE SILVEIRA ; FERREIRA, HENRIQUE BUNSELMEYER ; DE VASCONCELOS, ANA TEREZA RIBEIRO ; ZAHA, ARNALDO. New insights on the biology of swine respiratory tract mycoplasmas from a comparative genome analysis. BMC Genomics, v. 14, p. 175-, 2013. |
| Autor | Francisco Prosdocimi |
| Ano | 2013 |
Informações Complementares
| Ano do artigo | 2013 |
| Descricão e Informacões Adicionais | Mycoplasma hyopneumoniae, Mycoplasma flocculare and Mycoplasma hyorhinis live in swine respiratory tracts. M. flocculare, a commensal bacterium, is genetically closely related to M. hyopneumoniae, the causative agent of enzootic porcine pneumonia. M. hyorhinis is also pathogenic, causing polyserositis and arthritis. In this work, we present the genome sequences of M. flocculare and M. hyopneumoniae strain 7422, and we compare these genomes with the genomes of other M. hyoponeumoniae strain and to the a M. hyorhinis genome. These analyses were performed to identify possible characteristics that may help to explain the different behaviors of these species in swine respiratory tracts. The overall genome organization of three species was analyzed, revealing that the ORF clusters (OCs) differ considerably and that inversions and rearrangements are common. Although M. flocculare and M. hyopneumoniae display a high degree of similarity with respect to the gene content, only some genomic regions display considerable synteny. Genes encoding proteins that may be involved in host-cell adhesion in M. hyopneumoniae and M. flocculare display differences in genomic structure and organization. Some genes encoding adhesins of the P97 family are absent in M. flocculare and some contain sequence differences or lack of domains that are considered to be important for adhesion to host cells. The phylogenetic relationship of the three species was confirmed by a phylogenomic approach. The set of genes involved in metabolism, especially in the uptake of precursors for nucleic acids synthesis and nucleotide metabolism, display some differences in copy number and the presence/absence in the three species. The comparative analyses of three mycoplasma species that inhabit the swine respiratory tract facilitated the identification of some characteristics that may be related to their different behaviors. M. hyopneumoniae and M. flocculare display many differences that may help to explain wh |
| Divulgacão Científica | NAO |
| DOI | 10.1186/1471-2164-14-175 |
| Homepage do Trabalho | [doi:10.1186/1471-2164-14-175] |
| Idioma | Inglês |
| ISSN | 14712164 |
| Meio de Divulgação | MEIO_DIGITAL |
| Natureza | COMPLETO |
| Página Inicial | 175 |
| Relevância | NAO |
| Série | 1 |
| Título do Artigo | New insights on the biology of swine respiratory tract mycoplasmas from a comparative genome analysis |
| Título do Períodico ou Revista | BMC Genomics |
| Volume | 14 |