Detalhes da Produção

Tipo	Artigo Publicado
Grupo	Produção Bibliográfica
Descrição	de Paula, A.A.N. ; Martins, J.B.L. ; dos Santos, M.L. ; NASCENTE, L. C. ; Romeiro, Luiz A.S. ; Areas, T.F.M.A. ; Vieira, K.S.T. ; Gambôa, N.F. ; Castro, N.G. ; GARGANO, Ricardo ; MARTINS, J. B. L.. New potential AChE inhibitor candidates. European Journal of Medicinal Chemistry, v. 44, p. 3754-3759, 2009.
Autor	Luciana de Camargo Nascente
Ano	2009

Ano do artigo	2009
Descricão e Informacões Adicionais	We have theoretically studied new potential candidates of acetylcholinesterase (AChE) inhibitors designed from cardanol, a non-isoprenoid phenolic lipid of cashew Anacardium occidentale nut-shell liquid. The electronic structure calculations of fifteen molecules derivatives from cardanol were performed using B3LYP level with 6-31G, 6-31G(d), and 6-311+G(2d,p) basis functions. For this study we used the following groups: methyl, acetyl, N,N-dimethylcarbamoyl, N,N-dimethylamine, N,N-diethylamine, piperidine, pyrrolidine, and N,N-methylbenzylamine. Among the proposed compounds we identi ed that the structures with substitution by N,N-dimethyl-carbamoyl, N,N-dimethylamine, and pyrrolidine groups were better correlated to rivastigmine, and represent possible AChE inhibitors against Alzheimer disease.
Divulgacão Científica	NAO
DOI	10.1016/j.ejmech.2009.03.045
Idioma	Inglês
ISSN	02235234
Meio de Divulgação	MEIO_DIGITAL
Natureza	COMPLETO
Página Final	3759
Página Inicial	3754
Relevância	NAO
Título do Artigo	New potential AChE inhibitor candidates
Título do Períodico ou Revista	European Journal of Medicinal Chemistry
Volume	44