Detalhes da Produção

Tipo	Artigo Publicado
Grupo	Produção Bibliográfica
Descrição	Bronzoni, Roberta V. M. ; Madrid, Maria C. F. S. ; Duarte, Danilo V. B. ; Pellegrini, Vanessa O. A. ; Pacca, Carolina C. ; Carmo, Ana C. V. ; Zanelli, Cleslei F. ; Valentini, Sandro R. ; Santacruz-Pérez, Carolina ; Barbosa, João A. R. G. ; Lutz, Carol S. ; Rahal, Paula ; Nogueira, Maurício L.. The small nuclear ribonucleoprotein U1A interacts with NS5 from yellow fever virus. Archives of Virology, v. 156, p. 931-938, 2011.
Autor	João Alexandre Ribeiro Gonçalves Barbosa
Ano	2011

Ano do artigo	2011
Descricão e Informacões Adicionais(en)	The flavivirus NS5 protein is one of the most important proteins of the replication complex, and cellular proteins can interact with it. This study shows for the first time that the yellow fever virus (YFV) NS5 protein is able to interact with U1A, a protein involved in splicing and polyadenylation. We confirmed this interaction by GST-pulldown assay and by co-immunoprecipitation in YFV-infected cells. A region between amino acids 368 and 448 was identified as the site of interaction of the NS5 protein with U1A. This region was conserved among some flaviviruses of medical importance. The implications of this interaction for flavivirus replication are discussed.
Divulgacão Científica	NAO
DOI	10.1007/s00705-011-0927-x
Homepage do Trabalho	[doi:10.1007/s00705-011-0927-x]
Idioma	Inglês
ISSN	03048608
Meio de Divulgação	MEIO_DIGITAL
Natureza	COMPLETO
Página Final	938
Página Inicial	931
Relevância	NAO
Título do Artigo	The small nuclear ribonucleoprotein U1A interacts with NS5 from yellow fever virus
Título do Períodico ou Revista	Archives of Virology
Volume	156